Variability in the response of canine and human dendritic cells stimulated with Brucella canis

Variability in the response of canine and human dendritic cells stimulated with Brucella canis

Brucella canis is a small intracellular Gram-negative bacterium whose primary host is the dog, but it also can cause mild human brucellosis. One of the main causes of an inefficient immune response against other species of Brucella is their interaction with dendritic cells (DCs), which affects antigen presentation and impairs the development of an effective Th1 immune response. This study analy...

Canine Brucellosis: Brucella canis

Canine brucellosis, caused by Brucella canis, is an important cause of reproductive failure, particularly in kennels. This organism causes abortions, stillbirths, epididymitis, orchitis and sperm abnormalities in dogs. Although dogs that have been spayed or neutered do not have reproductive signs, they occasionally develop other conditions such as ocular disease and discospondylitis. B. canis c...

Proinflammatory response of canine trophoblasts to Brucella canis infection

Brucella canis infection is an important cause of late-term abortion in pregnant bitches. The pathophysiological mechanisms leading to B. canis-induced abortion are unknown, but heavily infected trophoblasts are consistently observed. As trophoblasts responses to other pathogens contribute to placental inflammation leading to abortion, the aim of the present study was to characterize the cytoki...

Canine Brucellosis Caused by Brucella Canis

Etiology and Epidemiology Canine brucellosis is caused by Brucella canis (B. canis), a rough, small, gram-negative, intracellular bacterium. Other Brucella species, i.e., B. abortus, B. suis, have occasionally caused canine infections but they are not discussed here. The canine brucella was first recognized in 1966 as a cause of abortions and reproductive failures and it has since been recogniz...

Improved Function and Maturation of Dendritic Cells Stimulated by Recombinant pp65 Protein: In vitro Design